USS Spruance (DDG-111) is a United States Navy Arleigh Burke-class destroyer. She is the 61st ship in her class.  USS Spruance is the second ship to be named for Admiral Raymond A. Spruance (1886–1969).


Admiral Spruance commanded U.S. naval forces during two of the most significant naval battles that took place in the Pacific Theatre in World War II: the Battle of Midway and the Battle of the Philippine Sea.


At Midway, Admiral Spruance scored the first major victory for the United States over Japan; most historians consider Midway the turning point of the Pacific War. He was later Ambassador to the Philippines.